No direct dose conversion
The medicines work differently and are dosed on different scales. No trial has matched their doses step by step, so there’s no approved conversion chart.
| Medicine | How it is taken | Licensed dose range | Available as a tailored plan |
|---|---|---|---|
| Mounjaro (tirzepatide) | Weekly injection | 2.5mg to 15mg | Yes |
| Wegovy (semaglutide) injection | Weekly injection | 0.25mg to 7.2mg | No |
| Wegovy (semaglutide) tablets | Daily tablet | 1.5mg to 25mg | No — a tablet cannot be dose-adjusted the way a pen can |
| Foundayo (orforglipron) | Daily tablet, any time of day, with or without food | 0.8mg to 17.2mg | No |
What your doctor considers
Your doctor also checks your other conditions, medicines, pregnancy plans and any upcoming surgery.
How you tolerated it
Often more useful than the dose you reached.
Why you’re switching
Side effects, cost, supply, plateau or preference.
The direction
A stronger medicine, a milder one, or injection to tablet.
How long you held your dose
A year at a dose is different from four weeks.
Losing or maintaining
Switching mid-loss differs from switching to hold.
The gap
These medicines clear slowly, so timing matters.
Injection to tablet
In the ATTAIN-MAINTAIN trial, 376 people at a plateau on semaglutide or tirzepatide switched to daily orforglipron or placebo. At 24 weeks, those switching from semaglutide averaged −0.1kg and those from tirzepatide +2.6kg, against about +9kg on placebo.
Eli Lilly topline results, December 2025, not yet peer reviewed. The evidence.
What to bring
Tell your doctor
- What you take, and the dose
- How long you’ve been on it
- How it affected you at first, and now
- Your last dose date, and your longest gap
- Anything taken from other sources
- What you currently pay
After a switch, expect a short adjustment period, much like starting for the first time.
Thinking of switching?
Bring your history to a free consultation.